@article{119981,
  author = {Dana A. Glei and Noreen Goldman and Chih-Hsun Wu and Macine Weinstein},
  title = {Does Exposure to Stressors Predict Changes in Physiological Dysregulation?},
  abstract = { <h3>
	Background
</h3>

<p>
	The allostatic load framework implies that cumulative exposure to stressors results in multi-system physiological dysregulation.
</p>

<h3>
	Purpose
</h3>

<p>
	The purpose of this study was to investigate the effect of stress burden on subsequent changes (2000{\textendash}2006) in physiological dysregulation.
</p>

<h3>
	Methods
</h3>

<p>
	Data came from a population-based cohort study in Taiwan (<em>n</em> = 521, aged 54+ in 2000, re-examined in 2006). Measures of stressful events and chronic strain were based on questions asked in 1996, 1999, and 2000. A measure of trauma was based on exposure to the 1999 earthquake. Dysregulation was based on 17 biomarkers (e.g., metabolic, inflammatory, neuroendocrine).
</p>

<h3>
	Results
</h3>

<p>
	There were some small effects among men: chronic strain was associated with subsequent increases in dysregulation (standardized~<em>β</em> = 0.08, 95~\% CI = 0.01 to 0.20), particularly inflammation; life events were also associated with increased inflammation (<em>β</em> = 0.10, CI = 0.01 to 0.26). There were no significant effects in women.
</p>
 },
  year = {2013},
  journal = {Annals of Behavioral Medicine},
  volume = {46},
  pages = {121-126},
  url = {https://link.springer.com/article/10.1007/s12160-013-9485-7},
  language = {eng},
}